Phenotypes Associated with This Genotype

Genotype
MGI:3027786

• Allelic Composition: Sema4d^tm1Kik/Sema4d^tm1Kik
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:66033 )

N • behavior was normal

cardiovascular system

cardiovascular system phenotype ( J:66033 )

N • Phenotype was normal in these tissues where Sema4d^tm1Kik interacts through plexin-B1 receptors rather than through CD72 receptors as in lymphoid tissue

hematopoietic system

decreased B cell proliferation ( J:66033 )

• cell proliferation was slower in vitro

increased B cell number ( J:66033 )

• increased numbers of CD23+B220+ B cells

decreased T cell number ( J:66033 )

• Il4 and Ifn-gamma T-cells reduced in numbers

decreased CD4-positive, alpha-beta T cell number ( J:66033 )

• reduced in numbers

abnormal B-1 B cell morphology ( J:66033 )

• B-1 cell development abnormality

decreased B-1a cell number ( J:66033 )

• considerable reduction in numbers of CD5+B220+ B cells

decreased spleen germinal center size ( J:66033 )

• germinal centers in the spleen were smaller and with fewer antigen specific IgG1 cells

abnormal immunoglobulin level ( J:66033 )

• impaired IgG1 response to T-cell dependent antigen but not to T-cell independent antigens

• no abnormalities in serum levels of the various Ig classes however

immune system

decreased B cell proliferation ( J:66033 )

• cell proliferation was slower in vitro

increased B cell number ( J:66033 )

• increased numbers of CD23+B220+ B cells

decreased T cell number ( J:66033 )

• Il4 and Ifn-gamma T-cells reduced in numbers

decreased CD4-positive, alpha-beta T cell number ( J:66033 )

• reduced in numbers

abnormal B-1 B cell morphology ( J:66033 )

• B-1 cell development abnormality

decreased B-1a cell number ( J:66033 )

• considerable reduction in numbers of CD5+B220+ B cells

decreased spleen germinal center size ( J:66033 )

• germinal centers in the spleen were smaller and with fewer antigen specific IgG1 cells

abnormal immunoglobulin level ( J:66033 )

• impaired IgG1 response to T-cell dependent antigen but not to T-cell independent antigens

• no abnormalities in serum levels of the various Ig classes however

renal/urinary system

renal/urinary system phenotype ( J:66033 )

N • Phenotype was normal in these tissues where Sema4d^tm1Kik interacts through plexin-B1 receptors rather than through CD72 receptors as in lymphoid tissue

nervous system

nervous system phenotype ( J:66033 )

N • Phenotype was normal in these tissues where Sema4d^tm1Kik interacts through plexin-B1 receptors rather than through CD72 receptors as in lymphoid tissue

cellular

decreased B cell proliferation ( J:66033 )

• cell proliferation was slower in vitro