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Phenotypes Associated with This Genotype
Genotype
MGI:3027717
Allelic
Composition		 Mst1rtm1Sjd/Mst1r+
Genetic
Background		 either: (involves: 129 * C57BL/6) or (involves: 129 * CD-1) or (involves: 129 * NIH Black Swiss)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mst1rtm1Sjd mutation (0 available); any Mst1r mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal macrophage physiology ( J:54903 )
• reduced peritoneal macrophage activation, assessed by morphological changes, after stimulation with hepatocyte growth factor
increased susceptibility to bacterial infection ( J:54903 )
• more susceptible to LPS-induced death than littermate controls

hematopoietic system
abnormal macrophage physiology ( J:54903 )
• reduced peritoneal macrophage activation, assessed by morphological changes, after stimulation with hepatocyte growth factor

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory