Phenotypes Associated with This Genotype

Genotype
MGI:3027423

• Allelic Composition: Ift172^wim/Ift172^wim
• Genetic Background: C3.B6J-Ift172^wim

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:86437 )

• development is arrested at E10.5-E11.5

cardiovascular system

abnormal direction of heart looping ( J:86437 )

• polarity of heart looping reversed in approximately 40% of E9.5 embryos

embryo

absent embryonic cilia ( J:86437 )

• node cells lack cilia

abnormal floor plate morphology ( J:86437 )

• lack the ventral midline groove in the neural plate

• markers of V3 interneurons and motorneurons were not expressed

open neural tube ( J:86437 )

nervous system

abnormal floor plate morphology ( J:86437 )

• lack the ventral midline groove in the neural plate

• markers of V3 interneurons and motorneurons were not expressed

open neural tube ( J:86437 )

cellular

absent embryonic cilia ( J:86437 )

• node cells lack cilia