Phenotypes Associated with This Genotype

Genotype
MGI:3027041

• Allelic Composition: Mre11a^tm1Jpt/Mre11a^tm1Jpt
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell cycle checkpoint function ( J:87088 , J:103922 )

• checkpoint defects; MEFs fail to arrest or suffer attrition either in S phase or at the G2/M border (J:87088)

• MEFs exhibit defects in G1/S, intra-S-phase, and G2/M checkpoints after ionizing radiation induced DNA damage (J:103922)

increased cellular sensitivity to ionizing radiation ( J:87088 , J:103922 )

• mouse embryonic fibroblasts (MEFs) are sensitive to ionizing radiation (J:87088)

• MEFs exhibit increased sensitivity to ionizing radiation (J:103922)

chromosomal instability ( J:87088 )

• passage 7 MEFs show chromosomal instability; 43% vs. 19% of wild-type metaphases contain at least 1 aberration and the number of aberrations per metaphase is increased

• 33% of early passage MEFs (p3) and 65% of late passage (greater than 5) MEFs show aberrant metaphases

• translocasions and fusions are seen in 5 of 32 early and 7 of 27 late passage MEFs

• 18% of metaphases in splenocyte cultures exhibit aberrations

chromosome breakage ( J:103922 )

induced chromosome breakage ( J:87088 )

• MEFs are hypersensitive to irradiation-induced chromosome breakage

maternal effect ( J:87088 )

• embryonic viability is drastically reduced in homozygous mothers but not in heterozygous intercrosses, indicating a maternal effect on viability

reproductive system

reduced female fertility ( J:87088 )

♀

neoplasm

neoplasm ( J:87088 )

N • inspite of cell cycle checkpoint failure and chromosomal instability, mice are not prone to malignancy including lymphomagenesis