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Phenotypes Associated with This Genotype
Genotype
MGI:3027041
Allelic
Composition
Mre11atm1Jpt/Mre11atm1Jpt
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mre11atm1Jpt mutation (1 available); any Mre11a mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• checkpoint defects; MEFs fail to arrest or suffer attrition either in S phase or at the G2/M border (J:87088)
• MEFs exhibit defects in G1/S, intra-S-phase, and G2/M checkpoints after ionizing radiation induced DNA damage (J:103922)
• mouse embryonic fibroblasts (MEFs) are sensitive to ionizing radiation (J:87088)
• MEFs exhibit increased sensitivity to ionizing radiation (J:103922)
• passage 7 MEFs show chromosomal instability; 43% vs. 19% of wild-type metaphases contain at least 1 aberration and the number of aberrations per metaphase is increased
• 33% of early passage MEFs (p3) and 65% of late passage (greater than 5) MEFs show aberrant metaphases
• translocasions and fusions are seen in 5 of 32 early and 7 of 27 late passage MEFs
• 18% of metaphases in splenocyte cultures exhibit aberrations
• MEFs are hypersensitive to irradiation-induced chromosome breakage
• embryonic viability is drastically reduced in homozygous mothers but not in heterozygous intercrosses, indicating a maternal effect on viability

reproductive system

neoplasm
N
• inspite of cell cycle checkpoint failure and chromosomal instability, mice are not prone to malignancy including lymphomagenesis


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory