Phenotypes Associated with This Genotype

Genotype
MGI:2687398

• Allelic Composition: Pax3^tm1Buck/Pax3^Sp
• Genetic Background: involves: 129P2/OlaHsd * C57BL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:86911 )

• stated to display the same phenotype as Pax3^Sp mice; however, no data is provided in J:86911

nervous system

open neural tube ( J:86911 )

• stated to display the same phenotype as Pax3^Sp mice

exencephaly ( J:86911 )

• stated to display the same phenotype as Pax3^Sp mice

• incidence is less than the incidence of spina bifida

absent dorsal root ganglion ( J:86911 )

muscle

abnormal myogenesis ( J:86911 )

• stated to display the same phenotype as Pax3^Sp mice including absence of limb muscles at E11.5

abnormal dermomyotome development ( J:86911 )

• stated to display the same phenotype as Pax3^Sp

embryo

abnormal neural crest cell migration ( J:86911 )

• impaired

open neural tube ( J:86911 )

• stated to display the same phenotype as Pax3^Sp mice

cellular

abnormal neural crest cell migration ( J:86911 )

• impaired