Phenotypes for Pax3 MGI:2687398 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Pax3^tm1Buck/Pax3^Sp
Genetic Background	involves: 129P2/OlaHsd * C57BL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax3^Sp mutation (4 available); any Pax3 mutation (50 available)
Pax3^tm1Buck mutation (1 available); any Pax3 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:86911 )

• stated to display the same phenotype as Pax3^Sp mice; however, no data is provided in J:86911

nervous system

open neural tube ( J:86911 )

• stated to display the same phenotype as Pax3^Sp mice

exencephaly ( J:86911 )

• stated to display the same phenotype as Pax3^Sp mice

• incidence is less than the incidence of spina bifida

absent dorsal root ganglion ( J:86911 )

muscle

abnormal myogenesis ( J:86911 )

• stated to display the same phenotype as Pax3^Sp mice including absence of limb muscles at E11.5

abnormal dermomyotome development ( J:86911 )

• stated to display the same phenotype as Pax3^Sp

embryo

abnormal neural crest cell migration ( J:86911 )

• impaired

open neural tube ( J:86911 )

• stated to display the same phenotype as Pax3^Sp mice

cellular

abnormal neural crest cell migration ( J:86911 )

• impaired

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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