Phenotypes Associated with This Genotype

Genotype
MGI:2687391

• Allelic Composition: Pax3^tm1Buck/Pax3^tm1Buck
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:86911 )

• stated to display the same phenotype as Pax3^Sp mice; however, no data is provided in J:86911

nervous system

abnormal neural tube morphology ( J:86911 )

• stated to display the same phenotype as Pax3^Sp mice; however, no data is provided in J:86911

spina bifida ( J:176192 )

• in all mice

exencephaly ( J:176192 )

• in 50% of mice

abnormal dorsal root ganglion morphology ( J:176192 )

• at E12.5, axons and spinal ganglia are severely reduced compared to in control mice

muscle

abnormal muscle precursor cell migration ( J:176192 )

• absent in forelimbs at E10.5

abnormal muscle development ( J:176192 )

• in the limb

abnormal myogenesis ( J:86911 )

• stated to display the same phenotype as Pax3^Sp mice; however, no data is provided in J:86911

abnormal myotome development ( J:176192 )

abnormal dermomyotome development ( J:176192 )

• in the epaxial and hypaxial dermomyotome

embryo

abnormal neural crest cell migration ( J:176192 )

• at E12.5, axons and spinal ganglia are severely reduced compared to in control mice

abnormal neural tube morphology ( J:86911 )

• stated to display the same phenotype as Pax3^Sp mice; however, no data is provided in J:86911

spina bifida ( J:176192 )

• in all mice

abnormal somite development ( J:86911 , J:176192 )

• somites are disorganized and truncated in the hypaxial and epaxial domains (J:86911)

• disorganized (J:176192)

cellular

abnormal muscle precursor cell migration ( J:176192 )

• absent in forelimbs at E10.5

abnormal neural crest cell migration ( J:176192 )

• at E12.5, axons and spinal ganglia are severely reduced compared to in control mice