Phenotypes Associated with This Genotype

Genotype
MGI:2687080

• Allelic Composition: Epha4^rb-2J/Epha4^rb-2J
• Genetic Background: C57BL/6J-Epha4^rb-2J/GrsrJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

limb grasping ( J:87289 )

• mice grasp their hind limbs when picked up by the tail

decreased grip strength ( J:87289 )

• mutants show a reduced ability to hold onto an edge

• forelimbs show normal strength

abnormal locomotor behavior ( J:87289 )

• unlike the less severe rb mutant, rb-2J mutant mice lean frequently to either side

abnormal locomotor coordination ( J:267074 )

• this allele causes leaning, not reported for other alleles

abnormal gait ( J:87289 )

• mutant mice can be identified by 2.5-3 weeks of age by a constant hopping gait of the hindlimbs

• the forelimbs may show a hopping gait or move normally

abnormal maternal nurturing ( J:87289 )

♀ • females are poor at nurturing their young

endocrine/exocrine glands

cryptorchism ( J:87289 )

♂ • males sometimes have undescended testes and fail to breed

reproductive system

cryptorchism ( J:87289 )

♂ • males sometimes have undescended testes and fail to breed

decreased litter size ( J:87289 )

• females produce small litters

reduced male fertility ( J:87289 )

♂ • due to undescended testes