adipose tissue
• less perigonadal adipose tissue
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growth/size/body
• liver is slightly increased in size compared to wild-type
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homeostasis/metabolism
• 37- and 7.7-fold increase of the plant sterols beta-sitosterol and campesterol , respectively, in the plasma relative to controls
• plasma levels of the plant sterols stigmasterol and brassicasterol are increased
• plasma plant sterol concentrations are further elevated when treated with the synthetic LXR agonist T0901317 unlike in wild-type where they are lowered
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• plasma triglycerides are elevated, predominantly in the very-low-density lipoprotein-sized lipoprotein fractions
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• cholesterol content is reduced in gallbladder bile
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• 60% that of controls
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• phospholipid concentration in the gallbladder bile is decreased, however the cholesterol/phospholipid ratio is unchanged
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• retention of orally administered radiolabeled beta-sitosterol is increased in the small intestine, liver, and plasma 24 hours after administration
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liver/biliary system
• liver is slightly increased in size compared to wild-type
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• accumulation of plant sterols in the liver
• however, do not observe steatosis
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reproductive system