Phenotypes Associated with This Genotype

Genotype
MGI:2684654

• Allelic Composition: Tg(APPV717I)1130Kha/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:29880 )

• 50% dead at 87 days of age

behavior/neurological

abnormal fear/anxiety-related behavior ( J:29880 )

• 84% neophobic at 100 days of age

reproductive system

reduced fertility ( J:29880 )

• poor breeders

nervous system

abnormal astrocyte morphology ( J:29880 )

• hypertrophic astrocytes in the parahippocampal area, hippocampus, amygdala, and cerebral cortex

cellular

abnormal astrocyte morphology ( J:29880 )

• hypertrophic astrocytes in the parahippocampal area, hippocampus, amygdala, and cerebral cortex