Phenotypes Associated with This Genotype

Genotype
MGI:2684468

• Allelic Composition: Kl^tm1Yin/Kl^tm1Yin
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:86859 )

• average life span of 77 days

• mice fed a vitamin D deficient diet survived past 15 weeks of age

adipose tissue

decreased white adipose tissue amount ( J:86859 )

growth/size/body

decreased body weight ( J:86859 )

• mice fed a vitamin D deficient diet reached normal weight

postnatal growth retardation ( J:86859 )

homeostasis/metabolism

increased circulating calcium level ( J:86859 )

• ectopic calcification observed in the kidney, aorta, stomach, gut, lung, and choroid plexus

• serum calcium levels were normal in mice on vitamin D deficient diet and no ectopic calcification was observed

• a calcium deficient diet rescuedt the calcification phenotype, but not the body weight phenotype

increased circulating phosphate level ( J:86859 )

• though elevated in mice fed a normal diet, serum phosphorous levels were normal in mice on vitamin D deficient diet

• a phosphorous deficient diet did not rescue either the calcifcation or body weight phenotypes

abnormal vitamin D level ( J:86859 )

• marked increase in serum levels of 1,25-dihydroxyvitamin D3 (1,25-(OH)2D)

• a vitamin D deficient diet rescued most phenotypes

skeleton

abnormal long bone epiphysis morphology ( J:86859 )

• abnormal calcification

• normal calcification observed in mice on a vitamin D deficient diet

decreased bone mineral density ( J:86859 )

• reduced bone density in the diaphysis

• normal bone density observed in mice on a vitamin D deficient diet