Phenotypes Associated with This Genotype

Genotype
MGI:2684337

• Allelic Composition: Gt(ROSA)26Sor^{tm1(Notch1)Dam}/Gt(ROSA)26Sor⁺; Tg(Pdx1-cre)89.1Dam/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal exocrine pancreas morphology ( J:86975 )

• differentiation of exocrine lineages is impaired; progenitors remain trapped in an undifferentiated state

endocrine/exocrine glands

abnormal exocrine pancreas morphology ( J:86975 )

• differentiation of exocrine lineages is impaired; progenitors remain trapped in an undifferentiated state

abnormal endocrine pancreas morphology ( J:86975 )

• differentiation of endocrine lineages is impaired; progenitors remain trapped in an undifferentiated state

decreased pancreatic alpha cell number ( J:86975 )

• at E15.5, alpha cell numbers are reduced 8-fold

decreased pancreatic beta cell number ( J:86975 )

• at E15.5, beta cell numbers are reduced nearly 100-fold

abnormal pancreas development ( J:86975 )

• pancreatic epithelium at E17.5 is translucent, cystic and comprised of highly branched, tubular epithelium with few distinct acini

• newborn pancreas exhibits convoluted epithelium in a fibroblastic stroma instead of acinar and islet tissue

• differentiation of exocrine and endocrine progenitor cells is impaired