Phenotypes Associated with This Genotype

Genotype
MGI:2683905

• Allelic Composition: Flt3^tm1Irl/Flt3^tm1Irl
• Genetic Background: either: 129S/SvEv-Flt3^tm1Irl or (involves: 129S/SvEv * C57BL/6J)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal B cell differentiation ( J:27238 , J:99149 )

• percentage of bone marrow B220+ cells is reduced (J:27238)

• Background Sensitivity: 10 fold reduction of primitive B lymphoid progenitors is less severe on a mixed background than on an inbred 129S/SvEv background (J:27238)

• early T lineage precursors lose the ability generate B cells (J:99149)

decreased pro-B cell number ( J:27238 )

• significantly reduced pro-B cell numbers, 49% normal

decreased pre-B cell number ( J:27238 )

• moderately reduced in numbers, 74% normal

hematopoietic system

abnormal B cell differentiation ( J:27238 , J:99149 )

• percentage of bone marrow B220+ cells is reduced (J:27238)

• Background Sensitivity: 10 fold reduction of primitive B lymphoid progenitors is less severe on a mixed background than on an inbred 129S/SvEv background (J:27238)

• early T lineage precursors lose the ability generate B cells (J:99149)

decreased pro-B cell number ( J:27238 )

• significantly reduced pro-B cell numbers, 49% normal

decreased pre-B cell number ( J:27238 )

• moderately reduced in numbers, 74% normal