Phenotypes Associated with This Genotype

Genotype
MGI:2683842

• Allelic Composition: Becn1^tm1Htz/Becn1⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Increased cancer rate in Becn1^tm1Htz/Becn1⁺ mice

neoplasm

increased tumor incidence ( J:86982 )

• 59% of mutants develop tumors compared to 14% of wild-type mice between 18 and 22 months of age; tumors are larger and of different types than in wild-type

• however, do not observe loss of heterozygosity in tumors

increased hepatocellular carcinoma incidence ( J:86982 )

increased B cell derived lymphoma incidence ( J:86982 )

increased lung adenocarcinoma incidence ( J:86982 )

respiratory system

increased lung adenocarcinoma incidence ( J:86982 )

liver/biliary system

increased hepatocellular carcinoma incidence ( J:86982 )