Phenotypes Associated with This Genotype

Genotype
MGI:2683489

• Allelic Composition: Lamc1^tm1Strl/Lamc1^tm1Strl; Tg(Mpz-cre)26Mes/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal axon radial sorting ( J:86714 )

• in mutant nerves, Schwann cells populate the nerve but fail to sort and myelinate axons

abnormal sciatic nerve morphology ( J:86714 )

• mutant sciatic nerves are undermyelinated even though many Schwann cells are present

abnormal myelination ( J:86714 )

• in mutant nerves, Schwann cells populate the nerve but fail to sort and myelinate axons

behavior/neurological

tremors ( J:86714 )

forelimb paralysis ( J:86714 )