Phenotypes for Lamc1 Tg(Mpz-cre)26Mes MGI:2683489 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Lamc1^tm1Strl/Lamc1^tm1Strl Tg(Mpz-cre)26Mes/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lamc1^tm1Strl mutation (1 available); any Lamc1 mutation (143 available)
Tg(Mpz-cre)26Mes mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal axon radial sorting ( J:86714 )

• in mutant nerves, Schwann cells populate the nerve but fail to sort and myelinate axons

abnormal sciatic nerve morphology ( J:86714 )

• mutant sciatic nerves are undermyelinated even though many Schwann cells are present

abnormal myelination ( J:86714 )

• in mutant nerves, Schwann cells populate the nerve but fail to sort and myelinate axons

behavior/neurological

tremors ( J:86714 )

forelimb paralysis ( J:86714 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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