Phenotypes Associated with This Genotype

Genotype
MGI:2682916

• Allelic Composition: H3f3a^{Gt(ROSABetageo)14E7Ev}/H3f3a^{Gt(ROSABetageo)14E7Ev}
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:58812 )

• approximately 50% of homozygous mutants died within 24 hours

behavior/neurological

abnormal grip strength ( J:58812 )

growth/size/body

postnatal growth retardation ( J:58812 )

• surviving homozygous mutants show significantly reduced growth rates

• culling of non-mutant pups resulted in normal growth rates of mutants, suggesting that reduced growth rate is due to competition with non-mutant littermates

reproductive system

reduced female fertility ( J:55812 )

♀ • in a small sample size, the proportion of infertile females among mutant animals was significantly different from wild-type

reduced male fertility ( J:55812 )

♂ • the number of copulations per male , as well as the number of pregnancies per copulatory event was significantly lower for mutant than for than of non mutants