Phenotypes Associated with This Genotype

Genotype
MGI:2682795

• Allelic Composition: Sox3^tm1.1Lja/Y
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased germ cell number ( J:86431 )

♂

oligozoospermia ( J:86431 )

♂

behavior/neurological

behavior/neurological phenotype ( J:86431 )

♂N • unlike human patients with mutations in the orthologous gene, mice did not show signs of mental retardation

skeleton

abnormal tooth morphology ( J:86431 )

♂ • overgrowth and misalignment of front teeth consistently observed

craniofacial

abnormal tooth morphology ( J:86431 )

♂ • overgrowth and misalignment of front teeth consistently observed

endocrine/exocrine glands

abnormal seminiferous tubule morphology ( J:86431 )

♂

abnormal Sertoli cell morphology ( J:86431 )

♂ • sertoli cell vacuolization

decreased testis weight ( J:86431 )

♂ • testes weight was 58% that of wild-type

growth/size/body

abnormal tooth morphology ( J:86431 )

♂ • overgrowth and misalignment of front teeth consistently observed

decreased body weight ( J:86431 )

♂ • incomplete penetrance of low body weight

reproductive system

decreased germ cell number ( J:86431 )

♂

abnormal seminiferous tubule morphology ( J:86431 )

♂

abnormal Sertoli cell morphology ( J:86431 )

♂ • sertoli cell vacuolization

decreased testis weight ( J:86431 )

♂ • testes weight was 58% that of wild-type

abnormal spermatogenesis ( J:86431 )

♂

oligozoospermia ( J:86431 )

♂