Phenotypes Associated with This Genotype

Genotype
MGI:2682666

• Allelic Composition: Sox3^tm1.1Lja/Sox3^tm1.1Lja
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal oocyte morphology ( J:86431 )

♀ • ovulation of defective oocytes

behavior/neurological

behavior/neurological phenotype ( J:86431 )

♀N • unlike human patients with mutations in the orthologous gene, mice did not show signs of mental retardation

skeleton

abnormal tooth morphology ( J:86431 )

♀ • overgrowth and misalignment of front teeth consistently observed

craniofacial

abnormal tooth morphology ( J:86431 )

♀ • overgrowth and misalignment of front teeth consistently observed

endocrine/exocrine glands

increased atretic ovarian follicle number ( J:86431 )

♀

abnormal ovarian folliculogenesis ( J:86431 )

♀ • excess follicular atresia though corpora lutea were present

growth/size/body

abnormal tooth morphology ( J:86431 )

♀ • overgrowth and misalignment of front teeth consistently observed

decreased body weight ( J:86431 )

♀ • incomplete penetrance of low body weight

reproductive system

abnormal oocyte morphology ( J:86431 )

♀ • ovulation of defective oocytes

abnormal female reproductive system morphology ( J:86431 )

♀ • ovaries developed, however defects associated with the formation of follicles and oocytes were observed

increased atretic ovarian follicle number ( J:86431 )

♀

abnormal ovarian folliculogenesis ( J:86431 )

♀ • excess follicular atresia though corpora lutea were present

reduced female fertility ( J:86431 )

♀