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Phenotypes Associated with This Genotype
Genotype
MGI:2681520
Allelic
Composition
Ghrtm1Arge/Ghrtm1Arge
Genetic
Background
involves: 129S/SvEv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ghrtm1Arge mutation (0 available); any Ghr mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• weight at birth and P10 is normal, however after 2 weeks post birth, mice show growth retardation (J:66913)
• weight at birth and P10 is normal, however after 2 weeks post birth, mice show growth retardation (J:66913)

reproductive system
• delay in sexual maturation of females (J:66913)
• delay in sexual maturation of females (J:66913)

hematopoietic system
• spleen size is disproportionately reduced in size (J:66913)
• spleen size is disproportionately reduced in size (J:66913)

homeostasis/metabolism
• serum IGF1 levels are undetectable (J:66913)
• serum IGF1 levels are undetectable (J:66913)

immune system
• spleen size is disproportionately reduced in size (J:66913)
• spleen size is disproportionately reduced in size (J:66913)

renal/urinary system
• kidney size is disproportionately reduced in size (J:66913)
• kidney size is disproportionately reduced in size (J:66913)

skeleton
• proliferative zone of chondrocytes is shorter at p22 and p30 (J:66913)
• chondrocyte proliferation in the proliferative zone is 63% of wild-type (J:66913)
• proliferative zone of chondrocytes is shorter at p22 and p30 (J:66913)
• chondrocyte proliferation in the proliferative zone is 63% of wild-type (J:66913)
• reduction in the rate of production and maturation of hypertrophic zone chondrocytes (J:66913)
• reduction in the rate of production and maturation of hypertrophic zone chondrocytes (J:66913)
• hypertrophic zone of chondrocytes is shorter at p22 and p30 (J:66913)
• hypertrophic zone of chondrocytes is shorter at p22 and p30 (J:66913)
• reduction in the height of the primary spongiosa (J:66913)
• reduction in the height of the primary spongiosa (J:66913)
• average height of a hypertrophic chondrocyte is only about 70% of the controls (J:66913)
• average height of a hypertrophic chondrocyte is only about 70% of the controls (J:66913)
• delay in development of diaphyseal, but not epiphyseal, secondary ossification centers (J:66913)
• delay in development of diaphyseal, but not epiphyseal, secondary ossification centers (J:66913)

Mouse Models of Human Disease
OMIM ID Ref(s)
Laron Syndrome 262500 J:66913


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory