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Phenotypes Associated with This Genotype
Genotype
MGI:2680904
Allelic
Composition
Abcd1tm1Kds/Abcd1tm1Kds
Genetic
Background
involves: 129/Sv * 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcd1tm1Kds mutation (0 available); any Abcd1 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• evident between 15 and 20 months of age
• on rotarod test, evident between 15 and 20 months of age
• reduced rearing, evident between 15 and 20 months of age

nervous system
• evident at 16 months of age, enlarged processes contained myelin-like figures
• evident at 16 months of age, in CNS
• evident at 16 months of age, in CNS, white matter had redundant sheaths that failed to contact axons and in PNS, focal hypermyelination of sciatic nerves
• evident at 15 months of age, increased latency of compound muscle action potential

Mouse Models of Human Disease
OMIM ID Ref(s)
Adrenoleukodystrophy; ALD 300100 J:75388


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory