Mouse Genome Informatics
hm
    Gbatm3Ggb/Gbatm3Ggb
involves: 129S5/SvEvBrd
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
cardiovascular system
• small accumulations of glucosylceramide (2X wild-type values) at 6.5 months of age

hematopoietic system
• small numbers of storage cells at 7 months of age
• small accumulations of glucsylceramide (2X wild-type values) at 6.5 months of age

immune system
• small numbers of storage cells at 7 months of age
• small accumulations of glucsylceramide (2X wild-type values) at 6.5 months of age

liver/biliary system
• small accumulations of glucosylceramide (2X wild-type values) at 6.5 months of age

respiratory system
• small accumulations of glucosylceramide (2X wild-type values) at 6.5 months of age

nervous system
• 42 week old mice exhibit accumulation of soluble and insoluble alpha-synuclein in the brain

Mouse Models of Human Disease
OMIM IDRef(s)
Gaucher Disease, Type I 230800 J:86334
Gaucher Disease, Type III 231000 J:86334