Phenotypes Associated with This Genotype

Genotype
MGI:2680286

• Allelic Composition: Tsix^tm1Enl/?
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:68136 )

• only 1 male and 1 female carrier born out of 104 mice

embryo

abnormal developmental patterning ( J:68136 )

abnormal gastrulation ( J:68136 )

abnormal germ layer development ( J:68136 )

abnormal mesoderm development ( J:68136 )

• at E7.5 mesoderm localized primarily at the embyonic/extraembryonic junction

absent egg cylinders ( J:68136 )

• at E6.5 failed to form well organized egg cylinder although all appropriate primitive tissues present

abnormal ectoplacental cone morphology ( J:68136 )

• at E7.5 the ectoplacental cone cells failed to expand into decidual tissue

abnormal allantois morphology ( J:68136 )

• disorganized at E8.5

small amniotic cavity ( J:68136 )

• at E6.5, the amniotic cavity is small

abnormal chorion morphology ( J:68136 )

• disorganized at E8.5

abnormal ectoplacental cavity morphology ( J:68136 )

• at E7.5, the ectoplacental cavity is small

abnormal extraembryonic coelom morphology ( J:68136 )

• at E7.5, exocoelom small and by E8.5 contains dead cells

abnormal visceral yolk sac morphology ( J:68136 )

• at E8.5, sometimes enlarged and containing disorganized embryonic tissue