Phenotypes Associated with This Genotype

Genotype
MGI:2680150

• Allelic Composition: Mef2a^tm1Eno/Mef2a^tm1Eno
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:79973 )

• increased lethality of mice that survived the postnatal between 1 and 9 months of age

• mice dying during this period did not exhibit dilated ventricles, but rather a reduction in the number of mitochondria in the heart

postnatal lethality, incomplete penetrance ( J:79973 )

• no growth retardation, fatigue, or inability to suckle

• lethality beginning 2 days after birth

• most died between 5 and 10 days after birth

• 90% had died by 3 weeks of age

• near 100% survival on a background involving 129/SvEvTac, C57BL/6, and FVB

cardiovascular system

dilated heart right ventricle ( J:79973 )

• detected after perinatal death, suggesting rapid progression and cardiac sudden death

• no evidence of myofiber hypertrophy, fatty infiltration, myocyte disarray, interstitial fibrosis, or defects of the ductus arteriosus, cardiac valves, or outflow tra

decreased heart rate ( J:79973 )

• severe bradycardia developing hours before death

respiratory system

respiratory system phenotype ( J:79973 )

N • no evidence of interstitial fibrosis, smooth muscle hyperplasia, stenosis, or thrombus formation in the pulmonary vasculature