Phenotypes Associated with This Genotype

Genotype
MGI:2679956

• Allelic Composition: Gna13^tm1Soff/Gna13^tm1Soff
• Genetic Background: involves: 129S1/Sv * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:50566 )

• homozygous embryos are indistinguishable from wild-type at E8.5, but appear poorly developed and misshaped by E9.5 and undergo resorbtion by E10.5

cardiovascular system

abnormal blood vessel morphology ( J:50566 )

• blood vessels in mutant embryos were enlarged, with defects in the endothelial layer; ectopic vasculature and sporadic discontinuities were also noted, suggesting a failure to develop a functional vasculature system

abnormal angiogenesis ( J:50566 )

• endothelial cells were present throughout mutant embryos; defects occurred in the sprouting, growth, migration and remodeling of endothelial cells

absent vitelline blood vessels ( J:50566 )

• no vascular structures were present in yolk

embryo

abnormal extraembryonic tissue morphology ( J:50566 )

absent vitelline blood vessels ( J:50566 )

• no vascular structures were present in yolk

pale yolk sac ( J:50566 )