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Phenotypes Associated with This Genotype
Genotype
MGI:2679898
Allelic
Composition		 Slc11a1tm1Mcg/Slc11a1s
Genetic
Background		 involves: 129S4/SvJae * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc11a1s mutation (0 available); any Slc11a1 mutation (38 available)
Slc11a1tm1Mcg mutation (0 available); any Slc11a1 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to bacterial infection ( J:28278 )
• compound heterozygous mice were susceptible to early phase infection with BCG or L. donovani or S. typhimurium
• mice showed rapid early BCG proliferation, a maximum bacterial load peaking at 3 weeks, and reduction of the BCG load by 6 weeks after infection

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory