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Phenotypes Associated with This Genotype
Genotype
MGI:2679609
Allelic
Composition
Lamc2tm1Uit/Lamc2tm1Uit
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lamc2tm1Uit mutation (1 available); any Lamc2 mutation (40 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• affected animals die by about day 5 postnatally

behavior/neurological
• by day 2, milk content in stomachs begins to drop

digestive/alimentary system
• separation of tissue layers in oral mucosa

renal/urinary system
• tissue layer separations in the epithelium

integument
• hypoplastic and rudimentary hemidesmosomes in the skin seen by transmission EM
• apoptosis in basal layers of skin
• dermal-epidermal tissues separating
• appears within 1-2 days of birth in 90% of mice
• mostly on paws and legs
• mice lacking blistering are smaller and weaker than wild-type

Mouse Models of Human Disease
OMIM ID Ref(s)
Epidermolysis Bullosa, Junctional, Herlitz Type 226700 J:85981


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory