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Phenotypes Associated with This Genotype
Genotype
MGI:2679609
Allelic
Composition
Lamc2tm1Uit/Lamc2tm1Uit
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lamc2tm1Uit mutation (1 available); any Lamc2 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• affected animals die by about day 5 postnatally (J:85981)
• affected animals die by about day 5 postnatally (J:85981)

behavior/neurological
• by day 2, milk content in stomachs begins to drop (J:85981)
• by day 2, milk content in stomachs begins to drop (J:85981)

digestive/alimentary system
• separation of tissue layers in oral mucosa (J:85981)
• separation of tissue layers in oral mucosa (J:85981)

renal/urinary system
• tissue layer separations in the epithelium (J:85981)
• tissue layer separations in the epithelium (J:85981)

integument
• hypoplastic and rudimentary hemidesmosomes in the skin seen by transmission EM (J:85981)
• apoptosis in basal layers of skin (J:85981)
• apoptosis in basal layers of skin (J:85981)
• hypoplastic and rudimentary hemidesmosomes in the skin seen by transmission EM (J:85981)
• dermal-epidermal tissues separating (J:85981)
• dermal-epidermal tissues separating (J:85981)
• appears within 1-2 days of birth in 90% of mice (J:85981)
• mostly on paws and legs (J:85981)
• mice lacking blistering are smaller and weaker than wild-type (J:85981)
• appears within 1-2 days of birth in 90% of mice (J:85981)
• mostly on paws and legs (J:85981)
• mice lacking blistering are smaller and weaker than wild-type (J:85981)

Mouse Models of Human Disease
OMIM ID Ref(s)
Epidermolysis Bullosa, Junctional, Herlitz Type 226700 J:85981


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory