Phenotypes Associated with This Genotype

Genotype
MGI:2679601

• Allelic Composition: Grb2^tm1Paw/Grb2^tm1Paw
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:51424 )

• no homozygous embryos were detectable at E7.5; homozygous embryos were seen at E3.5

embryo

absent inner cell mass proliferation ( J:51424 )

• inner cell mass did not expand

abnormal endoderm development ( J:51424 )

• very few endodermal cells were detectable at E3.5 or in cultured homozygous embryos

cellular

absent inner cell mass proliferation ( J:51424 )

• inner cell mass did not expand