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Phenotypes Associated with This Genotype
Genotype
MGI:2679510
Allelic
Composition
Hba-a1tm1Ywk/Hba-a1+
Genetic
Background
involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hba-a1tm1Ywk mutation (0 available); any Hba-a1 mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• heterozygotes are borderline anemic relative to wild-type controls
• however, heterozygotes are not hemolytic, as shown by normal reticulocyte counts
• heterozygotes display a borderline reduction in MCV, similar to that sometimes seen in human silent carriers, indicating a mild alpha-thalassemia phenotype

Mouse Models of Human Disease
OMIM ID Ref(s)
Hemoglobin--Alpha Locus 1; HBA1 141800 J:35018


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory