Mouse Genome Informatics
ht
    Hba-a1tm1Ywk/Hba-a1+
involves: 129X1/SvJ * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
hematopoietic system
• heterozygotes display a borderline reduction in MCV, similar to that sometimes seen in human silent carriers, indicating a mild alpha-thalassemia phenotype
• heterozygotes are borderline anemic relative to wild-type controls
• however, heterozygotes are not hemolytic, as shown by normal reticulocyte counts

Mouse Models of Human Disease
OMIM IDRef(s)
Hemoglobin--Alpha Locus 1; HBA1 141800 J:35018