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Phenotypes Associated with This Genotype
Genotype
MGI:2679368
Allelic
Composition		 Arnttm1.1Gonz/Arnttm1.2Gonz
Tg(Lck-cre)I57Jxm/0
Genetic
Background		 involves: 129X1/SvJ * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arnttm1.1Gonz mutation (0 available); any Arnt mutation (65 available)
Arnttm1.2Gonz mutation (0 available); any Arnt mutation (65 available)
Tg(Lck-cre)I57Jxm mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal immune system physiology ( J:85934 )
• resistance to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induced thymic involution

homeostasis/metabolism
decreased physiological sensitivity to xenobiotic ( J:85934 )
• resistance to the environmental pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induced thymic involution

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory