Mouse Genome Informatics
hm
    Limk1tm1Zpj/Limk1tm1Zpj
involves: 129/Sv
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
behavior/neurological
• impaired learning during learning reversal phase in a Morris water test
• greater response in cued-conditioning fear response

nervous system
• size of growth cone in hippocampal neurons greatly reduced
• actin cytoskeleton disrupted
• abnormal clusters of cofilin and actin
• abnormal shape of dendritic spines
• long term potentiation by high frequency stimulation enhanced while it was reduced or absent at low frequency
• reduced neurotransmitter release
• effect due to actin perturbation

Mouse Models of Human Disease
OMIM IDRef(s)
Williams-Beuren Syndrome; WBS 194050 J:86283