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Phenotypes Associated with This Genotype
Genotype
MGI:2679324
Allelic
Composition
Limk1tm1Zpj/Limk1tm1Zpj
Genetic
Background
involves: 129/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Limk1tm1Zpj mutation (0 available); any Limk1 mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• impaired learning during learning reversal phase in a Morris water test
• greater response in cued-conditioning fear response

nervous system
• size of growth cone in hippocampal neurons greatly reduced
• actin cytoskeleton disrupted
• abnormal clusters of cofilin and actin
• abnormal shape of dendritic spines
• long term potentiation by high frequency stimulation enhanced while it was reduced or absent at low frequency
• reduced neurotransmitter release
• effect due to actin perturbation

Mouse Models of Human Disease
OMIM ID Ref(s)
Williams-Beuren Syndrome; WBS 194050 J:86283


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory