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Phenotypes Associated with This Genotype
Genotype
MGI:2679084
Allelic
Composition
Bmp4tm1Blh/Bmp4tm3.1Blh
Tg(Tnnt2-cre)5Blh/0
Genetic
Background
involves: 129S/Sv * Black Swiss * C57BL/6 * DBA/2 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4tm1Blh mutation (2 available); any Bmp4 mutation (5 available)
Bmp4tm3.1Blh mutation (0 available); any Bmp4 mutation (5 available)
Tg(Tnnt2-cre)5Blh mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no neonates are found (J:86001)
• no neonates are found (J:86001)

cardiovascular system
• at E12.5 about a 20% decrease in proliferation is detected in the atrioventricular cushions but not in other areas of the heart (J:86001)
• at E12.5 about a 20% decrease in proliferation is detected in the atrioventricular cushions but not in other areas of the heart (J:86001)
• present in 80% of embryos at E15.5 - E16.5 (J:86001)
• present in 80% of embryos at E15.5 - E16.5 (J:86001)
• single atrioventricular junction with a common valve (J:86001)
• single atrioventricular junction with a common valve (J:86001)

Mouse Models of Human Disease
OMIM ID Ref(s)
Atrioventricular Septal Defect; AVSD 606215 J:86001


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory