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Phenotypes Associated with This Genotype
Genotype
MGI:2679018
Allelic
Composition		 Ikbkbtm1Cgn/Ikbkbtm1Cgn
Tg(Lck-cre)I57Jxm/0
Genetic
Background		 involves: C57BL/6 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikbkbtm1Cgn mutation (0 available); any Ikbkb mutation (56 available)
Tg(Lck-cre)I57Jxm mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased CD4-positive, alpha-beta T cell number ( J:85810 )
• CD4+ T cell numbers are reduced in the spleen and lymph nodes
decreased CD8-positive, alpha-beta T cell number ( J:85810 )
• CD8+ T cell numbers are reduced in the spleen and lymph nodes

hematopoietic system
decreased CD4-positive, alpha-beta T cell number ( J:85810 )
• CD4+ T cell numbers are reduced in the spleen and lymph nodes
decreased CD8-positive, alpha-beta T cell number ( J:85810 )
• CD8+ T cell numbers are reduced in the spleen and lymph nodes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory