Phenotypes Associated with This Genotype

Genotype
MGI:2678685

• Allelic Composition: Gli2^tm1Alj/Gli2^tm1Alj; Gli3^Xt-J/Gli3⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

mandible hypoplasia ( J:38381 )

• coronoid, condylar, angular and dental processes are hypoplastic

limbs/digits/tail

abnormal digit morphology ( J:38381 )

• on forelimbs, there is a postaxial stub of an extra digit

polydactyly ( J:38381 )

• display more severe preaxial polydactyly compared to Gli2 homozygotes

short humerus ( J:38381 )

• shortening of the humerus

short radius ( J:38381 )

• shortening of the radius; shortening is more severe than in the ulna

short ulna ( J:38381 )

• shortening of the ulna, although not as severe as the radius

short femur ( J:38381 )

short fibula ( J:38381 )

• not as severe as the tibia

short tibia ( J:38381 )

skeleton

abnormal skeleton morphology ( J:38381 )

• show an exacerbated phenotype in various skeletal elements with respect to Gli2 nulls

mandible hypoplasia ( J:38381 )

• coronoid, condylar, angular and dental processes are hypoplastic

abnormal long bone morphology ( J:38381 )

short humerus ( J:38381 )

• shortening of the humerus

short radius ( J:38381 )

• shortening of the radius; shortening is more severe than in the ulna

short ulna ( J:38381 )

• shortening of the ulna, although not as severe as the radius

short femur ( J:38381 )

short fibula ( J:38381 )

• not as severe as the tibia

short tibia ( J:38381 )

split sternum ( J:38381 )

• sternum is split rostrally and improperly segmented

abnormal vertebrae development ( J:38381 )

• there are severe abnormalities in chondrogenesis of ventral vertebral components

abnormal cartilage development ( J:38381 )

• there are severe abnormalities in chondrogenesis of ventral vertebral components

growth/size/body

mandible hypoplasia ( J:38381 )

• coronoid, condylar, angular and dental processes are hypoplastic