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Phenotypes Associated with This Genotype
Genotype
MGI:2678480
Allelic
Composition		 Hprt1b-m3/Y
Impdh2tm1Bmi/Impdh2+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1b-m3 mutation (4 available); any Hprt1 mutation (1280 available)
Impdh2tm1Bmi mutation (0 available); any Impdh2 mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal lymphocyte cell number ( J:86045 )
• inhibited of proliferation due to anti-CD3+anti-CD28
• approximately 30% reduction of intracellular GTP when stimulated by anti-CD3 + anti-CD28
• T cells more sensitive than B cells to guanine synthesis
• greater sensitivity to MPA inhibitition of IMPDH
abnormal cytotoxic T cell physiology ( J:86045 )
• a 20-30% reduction of T cell cytolytic activity

hematopoietic system
abnormal lymphocyte cell number ( J:86045 )
• inhibited of proliferation due to anti-CD3+anti-CD28
• approximately 30% reduction of intracellular GTP when stimulated by anti-CD3 + anti-CD28
• T cells more sensitive than B cells to guanine synthesis
• greater sensitivity to MPA inhibitition of IMPDH
abnormal cytotoxic T cell physiology ( J:86045 )
• a 20-30% reduction of T cell cytolytic activity

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory