Phenotypes Associated with This Genotype

Genotype
MGI:2678339

• Allelic Composition: Mnt^tm1.1Phu/Mnt^tm1.1Phu
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:85481 )

• homozygotes die within a few days of birth

cellular

abnormal cell physiology ( J:85481 )

• MEFs obtained at E13.5

• at early passages show improved growth rates and higher cell densities

• enter more quickly into S phase

• higher apoptosis levels in culture 24 hours after serum withdrawl

• faster development of immortalized cell lines

• MEFs infected with c-Myc and H-Ras viruses develop higher numbers of transformed foci

• transformed cells capable of anchorage independent growth

embryo

decreased embryo size ( J:85481 )

• apparent by E13.5

growth/size/body

decreased embryo size ( J:85481 )

• apparent by E13.5

decreased body size ( J:85481 )