Phenotypes Associated with This Genotype

Genotype
MGI:2678285

• Allelic Composition: Cops2^tm1Nwe/Cops2^tm1Nwe
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:85761 )

• no homozygous mice are born

• no viable post implantation homozygous embryos are recovered, but high numbers of empty decidua are found

• preimplantation E3.5 embryos are recovered, but embryos die soon after implantation

embryo

absent inner cell mass proliferation ( J:85761 )

• failure of the ICM to grow in cultured blastocysts; the presumed ICM from cultured blastocysts ceased proliferation by day 3 in culture, with all proliferation ending by day 4

abnormal gastrulation ( J:85761 )

absent egg cylinders ( J:85761 )

• layered egg cylinder structure absent at E6.5

• very few cells and no discernable differentiation at E6.5

abnormal inner cell mass morphology ( J:85761 )

• enlarged central nuclei in cells - atypical of ICM

• no increase in apoptosis

abnormal extraembryonic tissue morphology ( J:85761 )

decreased trophoblast giant cell number ( J:85761 )

• occasional trophoblast giant cells can be found

cellular

absent inner cell mass proliferation ( J:85761 )

• failure of the ICM to grow in cultured blastocysts; the presumed ICM from cultured blastocysts ceased proliferation by day 3 in culture, with all proliferation ending by day 4

reproductive system

empty decidua capsularis ( J:85761 )

• high numbers of empty decidua are found