Phenotypes Associated with This Genotype

Genotype
MGI:2678102

• Allelic Composition: Crhr1^tm2Wrst/Crhr1^tm2Wrst; Tg(Camk2a-cre)159Kln/0
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased anxiety-related response ( J:85745 )

• in the light-dark box paradigm, mutant mice spend significantly more time in the lit compartment, display a decresead latency to enter the lit compartment, and show a signicantly higher number of entries into the lit compartment than control mice; however, no significant differences in the number of entries into the dark compartment are observed

• in the elevated plus maze test, mutant mice display significantly fewer head-dips in the protected arms as a percentage of total head dips, and an increase in the percentage of entries into the open arms; however, no significant differences in the number of entries into the closed arms are observed

increased locomotor activity ( J:85745 )

• mutant mice display increased locomotor activity in the open-field paradigm

homeostasis/metabolism

increased circulating corticosterone level ( J:85745 )

• although basal plasma corticosterone levels are normal, mutant mice display significantly higher plasma corticosterone levels at 30 and 90 min after a 5-min restraint stress relative to similarly-stressed control mice

increased circulating adrenocorticotropin level ( J:85745 )

• although basal plasma ACTH levels are normal, mutant mice display significantly higher plasma ACTH levels at 30 and 90 min after a 5-min restraint stress relative to similarly-stressed control mice