Phenotypes Associated with This Genotype

Genotype
MGI:2677971

• Allelic Composition: Fabp3^tm1Bin/Fabp3^tm1Bin
• Genetic Background: involves: 129P2/OlaHsd * BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:54614 )

• 25% of homozygotes died during an exercise regimen of swimming compared to less than 5% of wild-type

cardiovascular system

increased heart weight ( J:54614 )

• heart weight and heart/body weight ratios are increased by about 10%

cardiac hypertrophy ( J:54614 )

• develop a regional cardiac hypertrophy at old age, which is restricted to the septum and ventricle muscle layers near the lumina of the heart chambers

• hypertrophy is accompanied by an enlargement of myocyte nuclei and muscle fiber diameter

increased cardiac muscle cell glucose uptake ( J:54614 )

• increased glucose uptake by the heart

homeostasis/metabolism

hypoglycemia ( J:54614 )

• increased glucose uptake by the heart leading to decreased plasma glucose levels

abnormal lipid homeostasis ( J:54614 )

• impaired long-chain fatty acid (LCFA) utilization by the heart, leading to increased glucose uptake by the heart

• associated with exercise intolerance

increased circulating free fatty acids level ( J:54614 )

behavior/neurological

fatigue ( J:54614 )

• reduction in exercise tolerance, with homozygotes exhibiting much more exhaustion than wild-type after an exercise regimen of swimming

muscle

increased cardiac muscle cell glucose uptake ( J:54614 )

• increased glucose uptake by the heart

cellular

increased cardiac muscle cell glucose uptake ( J:54614 )

• increased glucose uptake by the heart

growth/size/body

increased heart weight ( J:54614 )

• heart weight and heart/body weight ratios are increased by about 10%

cardiac hypertrophy ( J:54614 )

• develop a regional cardiac hypertrophy at old age, which is restricted to the septum and ventricle muscle layers near the lumina of the heart chambers

• hypertrophy is accompanied by an enlargement of myocyte nuclei and muscle fiber diameter