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Phenotypes Associated with This Genotype
Genotype
MGI:2677961
Allelic
Composition
Slc7a11sut/Slc7a11sut
Genetic
Background
C3H/HeSnJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc7a11sut mutation (1 available); any Slc7a11 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• yellow hair pigment is reduced; black pigment is unaffected
• most easily seen with agouti especially in the juvenile coat
• on nonagouti some reduction in yellow pigment can be seen in the pinna hairs only

hematopoietic system
• platelet serotonin concentration is slightly reduced; no change in adenine nucleotide concentration

homeostasis/metabolism
• platelet serotonin concentration is slightly reduced; no change in adenine nucleotide concentration
• model for mild storage pool deficiency
• mutant mice have a 3.4 fold greater bleeding time compared to sib controls

integument
• yellow hair pigment is reduced; black pigment is unaffected
• most easily seen with agouti especially in the juvenile coat
• on nonagouti some reduction in yellow pigment can be seen in the pinna hairs only

Mouse Models of Human Disease
OMIM ID Ref(s)
Storage Pool Platelet Disease 185050 J:31616


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory