About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:2677761
Allelic
Composition		 Vhltm1Lss/Vhltm1.1Lss
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vhltm1.1Lss mutation (0 available); any Vhl mutation (16 available)
Vhltm1Lss mutation (0 available); any Vhl mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased hepatic hemangioma incidence ( J:85513 )
• observed in 18% of mice between 4 and 12 months of age, putatively due to sporadic LOH
• smaller than those observed in Vhlhtm1Lss/ Vhlhtm1.1Lss;Tg(ACTB-cre)1Tes mice

reproductive system
oligozoospermia ( J:85513 )
• 2-fold reduction in sperm count relative to wild-type

liver/biliary system
increased hepatic hemangioma incidence ( J:85513 )
• observed in 18% of mice between 4 and 12 months of age, putatively due to sporadic LOH
• smaller than those observed in Vhlhtm1Lss/ Vhlhtm1.1Lss;Tg(ACTB-cre)1Tes mice

cellular
oligozoospermia ( J:85513 )
• 2-fold reduction in sperm count relative to wild-type

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
von Hippel-Lindau disease DOID:14175 OMIM:193300
 J:85513

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory