Phenotypes Associated with This Genotype

Genotype
MGI:2677211

• Allelic Composition: Igll1^tm1Shim/Igll1^tm1Shim; Vpreb1a^tm1Shim/Vpreb1a^tm1Shim; Vpreb1b^tm1Shim/Vpreb1b^tm1Shim
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal B cell differentiation ( J:76947 )

• cultured bone marrow cells do not express Vpreb or Igl-5 either on the cell surface or in the cytoplasm

• numbers of nucleated bone marrow cells reduced

• no impairment of transition from immature to mature B cells

• no impairment of transition from pre-BII to immature B cells

• impaired transition from pre-BI to pre-BII

decreased immature B cell number ( J:76947 )

• reduced numbers of immature B cells

increased late pro-B cell number ( J:76947 )

• together with pre-BI cells, numbers increase 2 fold in cultured bone marrow cells

decreased B cell number ( J:76947 )

decreased mature B cell number ( J:76947 )

• reduced numbers of mature B cells

decreased B-1a cell number ( J:76947 )

• reduced numbers of B1-a cells at 10 days of age

decreased pre-B cell number ( J:76947 )

• pre-BII cells are severely decreased in numbers (25 fold at 3 weeks and 12 fold at 8-9 weeks)

• 7 fold decrease in large cells and 15 fold decrease in small cells

immune system

immune system phenotype ( J:76947 )

N • serum levels of IgM were normal

abnormal B cell differentiation ( J:76947 )

• cultured bone marrow cells do not express Vpreb or Igl-5 either on the cell surface or in the cytoplasm

• numbers of nucleated bone marrow cells reduced

• no impairment of transition from immature to mature B cells

• no impairment of transition from pre-BII to immature B cells

• impaired transition from pre-BI to pre-BII

decreased immature B cell number ( J:76947 )

• reduced numbers of immature B cells

increased late pro-B cell number ( J:76947 )

• together with pre-BI cells, numbers increase 2 fold in cultured bone marrow cells

decreased B cell number ( J:76947 )

decreased mature B cell number ( J:76947 )

• reduced numbers of mature B cells

decreased B-1a cell number ( J:76947 )

• reduced numbers of B1-a cells at 10 days of age

decreased pre-B cell number ( J:76947 )

• pre-BII cells are severely decreased in numbers (25 fold at 3 weeks and 12 fold at 8-9 weeks)

• 7 fold decrease in large cells and 15 fold decrease in small cells