Phenotypes Associated with This Genotype

Genotype
MGI:2677036

• Allelic Composition: Brca1^tm1Cxd/Brca1^tm2Cxd; Tg(KRT5-cre)5132Jlj/0; Tg(KRT5-E2F1)2Dgj/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:85354 )

• fewer (6.25%) than the expected 12.5% of mutants were observed, indicating some lethality; time of analysis not specified

neoplasm

increased skin tumor incidence ( J:85354 )

• by 45 weeks of age, all mutants develop at least one skin tumor, with an average of four tumors per mouse

increased squamous cell carcinoma incidence ( J:85354 )

• skin tumors are all squamous cell carcinoma

decreased tumor latency ( J:85354 )

• all mutants develop tumors by 45 weeks of age, significantly sooner than Brca1^tm1Cxd/Brca1^tm2Cxd Tg(KRT5-cre)1Jlj/0 mice or Brca1^tm2Cxd/Brca1⁺ Tg(KRT5-cre)1Jlj/0 mice and by 70 weeks of age, 100% of mice exhibit tumors

integument

increased keratinocyte proliferation ( J:85354 )

• increase in basal keratinocyte proliferation

abnormal epidermal layer morphology ( J:85354 )

• mutants exhibit increased epidermal proliferation and apoptosis

increased skin tumor incidence ( J:85354 )

• by 45 weeks of age, all mutants develop at least one skin tumor, with an average of four tumors per mouse

cellular

increased keratinocyte proliferation ( J:85354 )

• increase in basal keratinocyte proliferation