Phenotypes Associated with This Genotype

Genotype
MGI:2677035

• Allelic Composition: Brca1^tm1Cxd/Brca1^tm2Cxd; Tg(KRT5-E2F1)2Dgj/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased tumor incidence ( J:85354 )

• 94.7% of mutants develop tumors at 70 weeks of age

increased mouth tumor incidence ( J:85354 )

• some females develop tumors in the oral epithelium

increased skin tumor incidence ( J:85354 )

• develop tumors in the skin

increased squamous cell carcinoma incidence ( J:85354 )

• females develop squamous cell carcinoma in the cervix and vaginal epithelium

increased papilloma incidence ( J:85354 )

• females develop papillomas in the cervix

increased reproductive system tumor incidence ( J:85354 )

• develop tumors of the reproductive tract; all females develop tumors, with the majority from the cervix (papillomas and squamous cell carcinoma) and vaginal epithelium (squamous cell carcinoma)

integument

increased keratinocyte proliferation ( J:85354 )

• increase in basal keratinocyte proliferation

abnormal epidermal layer morphology ( J:85354 )

• mutants exhibit increased epidermal proliferation and apoptosis

increased skin tumor incidence ( J:85354 )

• develop tumors in the skin

cellular

increased keratinocyte proliferation ( J:85354 )

• increase in basal keratinocyte proliferation

reproductive system

increased reproductive system tumor incidence ( J:85354 )

• develop tumors of the reproductive tract; all females develop tumors, with the majority from the cervix (papillomas and squamous cell carcinoma) and vaginal epithelium (squamous cell carcinoma)

craniofacial

increased mouth tumor incidence ( J:85354 )

• some females develop tumors in the oral epithelium

growth/size/body

increased mouth tumor incidence ( J:85354 )

• some females develop tumors in the oral epithelium