Analysis Tools
reproductive system
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• all male homozygotes produce smaller litters than controls, although the average litter size per male varies considerably, ranging from no pups born to litter sizes closer to the lower limit of normal variation
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• on a mixed genetic background, male homozygotes exhibit a variable reduction in fertility, with some showing complete sterility while others show litter sizes that are smaller than normal
• in contrast, female homozygotes are fertile
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• in spite of normal acrosome status, sperm number, morphology and motility, in vitro sperm-zona pellucida binding is impaired
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