Phenotypes Associated with This Genotype

Genotype
MGI:2675784

• Allelic Composition: Ctf1^tm1Msd/Ctf1^tm1Msd
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

motor neuron degeneration ( J:77294 )

• in the lumbar spinal cord, motoneuron loss is increased by 23% and 26% at P1 and P9, respectively

• in the thoracic spinal cord, motoneuron loss is increased by 29% and 43% at P1 and P9, respectively

• in the brachial spinal cord, motoneuron loss is increased by 30% and 40% at P1 and P9, respectively

• in the brainstem nuclei, facial motorneuron loss is increased by 24% and 22% at P1 and P9, respectively, by 20% at 4 weeks, and by 16% and 17% at 3 and 6 months, respectively, while hypoglossal motorneuron loss is increased by 23% at both P1 and P9

• however, no significant differences in motoneuron numbers are detected in the lumbar spinal cord at E13.5-E14.5 or in the facial nucleus at E15 relative to wild-type mice

• in addition, axotomized homozygotes show no significant further loss of motorneurons in the facial nucleus at 2 or 6 months relative to wild-type mice

behavior/neurological

decreased grip strength ( J:77294 )

• at 4 months of age, homozygotes display a significant reduction in grip strength relative to wild-type littermates

• however, loss of muscle strength does not result in any other obvious behavioral deficits