Analysis Tools
mortality/aging
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• homozygotes die in the first hours after birth due to respiratory failure
|
respiratory system
|
• only one right lung lobe, corresponding to single left lung lobe
|
small lung
(
J:81798
)
|
• lungs 1/4 to 1/3 normal size
|
|
• failed branching pattern, lateral bulges appear at E11.5 but branching does not continue
• proximodistal patterning normal
• reduced airway space and increased number of mesenchymal cells
|
|
• lungs fail to inflate at birth
|
|
• ultimate cause of death
|
nervous system
|
• normal neural tube
• small but significant expansion of ventral neuronal progenitors
|
digestive/alimentary system
|
• reduced in thickness while stomach mesenchyme increases
|
hematopoietic system
|
• deformed at E18.5
|
small spleen
(
J:85472
)
|
• reduced in mass at E18.5
|
immune system
|
• deformed at E18.5
|
small spleen
(
J:85472
)
|
• reduced in mass at E18.5
|
endocrine/exocrine glands
|
• slight but significant decrease in proliferative activity of beta cells
|
|
• disorganized and reduced in size, cross sectional area reduced 45%
|
|
• in severe cases, E18.5 dorsal and ventral pancreases fuse into a compact mass smaller in size than normal
• normal architecture of acinar cells
• ventral pancreas tissue, normally attached to the dorsal region of the duodenum, extends ventrally towards the mediolateral area of the duodenum
|
|
• at E18.5, some mutants display ectopic pancreas formation with patches of pancreatic tissue incorporated into the duodenum
|
growth/size/body
|
• only one right lung lobe, corresponding to single left lung lobe
|
embryo
|
• normal neural tube
• small but significant expansion of ventral neuronal progenitors
|
cellular
|
• slight but significant decrease in proliferative activity of beta cells
|
