Phenotypes for Cdk2 MGI:2675622 MGI Mouse

abnormal female reproductive system morphology ( J:85230 )

• oviducts and uterus normal

absent corpus luteum ( J:85230 )

absent ovarian follicles ( J:85230 )

ovary atrophy ( J:85230 )

• by day 120 ovaries are atrophic (15-20% normal size)

• frequently find epithelium lined cysts replacing ovarian tissue

abnormal gametogenesis ( J:85230 )

• failure of both oogenesis and spermatogenesis

abnormal oocyte morphology ( J:85230 )

• ovaries normal through E17.5 when oocytes reach pachytene stage of meiosis

• by day 1 after birth when oocytes should be in late diplotene stage, few oocytes are left and apoptosis is occurring

abnormal meiosis ( J:85230 )

• failure of chromosome pairing

• meiosis fails to proceed past the pachytene stage of prophase I

abnormal spermiogenesis ( J:85230 )

• testes normal to day 15 when germ cells are tetraploid primary sperm cells

• by day 20, an absence of expected round spermatids

• apoptosis of spermatocytes occuring at day 20

abnormal male reproductive system morphology ( J:85230 )

abnormal seminiferous tubule morphology ( J:85230 )

• normal proliferation of spermatogonia through day 30 when seminiferous tubules are almost completely depleted of germ cells

testicular atrophy ( J:85230 )

• by day 120, testes are atrophic (20% normal size)

• normal levels of spermatogonia, Sertoli and Leydig cells

• few primary spermatocytes

• no post meiotic cells

abnormal fertility/fecundity ( J:85230 )

infertility ( J:85230 )

• both sexes were totally sterile