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Phenotypes Associated with This Genotype
Genotype
MGI:2675294
Allelic
Composition		 Cd59atm1Song/Cd59atm1Song
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd59atm1Song mutation (2 available); any Cd59a mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal complement pathway ( J:76578 )
• erythrocytes are more susceptible to autologous and heterologous MAC lysis under conditions of induced complement activation by antibodies or cobra venom factor (CVF)
• however, erythrocytes have a normal lifespan in vivo and mice do not develop spontaneous hemolytic anemia

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory