Phenotypes Associated with This Genotype

Genotype
MGI:2675268

• Allelic Composition: Hoxb8^tm1.1Jdes/Hoxb8^tm1.1Jdes
• Genetic Background: involves: 129P2/OlaHsd * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal sternum morphology ( J:68720 )

• often a reduced number of segments

abnormal sternocostal joint morphology ( J:58621 )

• in 33% of mice, T1 and T2 ribs fused before attachment to sternum or attach at the same point in some mice

asymmetric rib joints ( J:68720 )

• unilateral shift in rib attachments in some mice

abnormal rib morphology ( J:68720 )

• various rib abnormalities

cervical vertebral transformation ( J:68720 )

• C7 to C6 transformation in some instances

nervous system

abnormal dorsal root ganglion morphology ( J:58621 )

• 2nd spinal ganglion (C2) abnormal - degeneration by E12.5 affecting shape and position

• all mice exhibit abnormal rostral and caudal left side C2 spinal ganglion

• 4 of 5 and 3 of 5 mice exhibit abnormal rostral and caudal moieties, respectively, of the right side of the C2 spinal ganglion

growth/size/body

postnatal growth retardation ( J:58621 )

• normal size at birth but growth lagged subsequently

• however, growth recovers after weaning

behavior/neurological

limb grasping ( J:58621 )

• both fore and hind limbs

• stretch limbs and then pull them back toward middle of body

abnormal gait ( J:58621 )

• hind limbs are raised higher than normal while walking

integument

skin lesions ( J:58621 )

• develop on the back in about 1/3 of mice during life

• can be large wounds

• sometimes extend into deeper tissues