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Phenotypes Associated with This Genotype
Genotype
MGI:2675251
Allelic
Composition
Men1tm1.2Zqw/Men1tm1.2Zqw
Tg(Ins2-cre)23Herr/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Men1tm1.2Zqw mutation (1 available); any Men1 mutation (17 available)
Tg(Ins2-cre)23Herr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• 41.5% of mice developed insulinomas by 6 months of age and by 10 months, 100% of mutants have advanced insulinomas (carcinomas)

endocrine/exocrine glands
• hyperplastic islets as early as 2 months of age, which progresses with aging
• 41.5% of mice developed insulinomas by 6 months of age and by 10 months, 100% of mutants have advanced insulinomas (carcinomas)

homeostasis/metabolism
• glucose levels decreased after 8 months of agae, as tumorigenesis progressed
• insulin levels increased starting at 4 months of age and continued to increase with age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
multiple endocrine neoplasia type 1 DOID:10017 OMIM:131100
J:85133


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory