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Phenotypes Associated with This Genotype
Genotype
MGI:2675118
Allelic
Composition
Rasgrp1lag/Rasgrp1lag
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rasgrp1lag mutation (0 available); any Rasgrp1 mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• T cells failed to proliferate vigorously following antigen encounter

hematopoietic system
• defects in positive selection
• activated B cells accumulate but show normal proliferation and apoptosis
• CD4+ T cells accumulated in the lymphoid tissues of older mice
• increased serum levels observed in aged mice
• deposits detected in glomeruli
• T cells showed reduced responses to antigen and failed to undergo activation induced cell death
• T cells failed to proliferate vigorously following antigen encounter

immune system
• defects in positive selection
• activated B cells accumulate but show normal proliferation and apoptosis
• CD4+ T cells accumulated in the lymphoid tissues of older mice
• increased serum levels observed in aged mice
• deposits detected in glomeruli
• T cells showed reduced responses to antigen and failed to undergo activation induced cell death
• T cells failed to proliferate vigorously following antigen encounter
• generalized lymphadenopathy involving the submandibular, axillary, iliac, inguinal, and mesenteric nodes
• 10-fold increases in size and cellularity were observed relative to wild-type
• submandibular, axillary, iliac, inguinal, and mesenteric lymph nodes showed 10-fold increases in size and cellularity relative to wild-type
• lymphoproliferative autoimmune syndrome similar to systemic lupus erythematosus (SLE)
• almost all mice developed a diffuse proliferative glomerulonephritis characterized by enlarged glomeruli

liver/biliary system

renal/urinary system
• reduced glomular capsule space
• glomeruli were enlarged, inflamed, hyperplastic, showed thickening of the mesangium, and IgG deposits
• almost all mice developed a diffuse proliferative glomerulonephritis characterized by enlarged glomeruli


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory